Background: Pre-eclampsia (PE) is a disease with worldwide significance to mothers andinfants; it may have health hazards that increase maternal, fetal and infant morbidity andmortality. Aim of the present study was to evaluate the maternal and neonatal outcomes ofpregnancy associated with pre-eclampsia. Sample& setting: A case-control prospectivestudy was selected in carrying out this study and a representative sample of two groups, onefrom women diagnosed with pre-eclampsia (100) and the other from normotensive women(100), were admitted to Zagazig University maternity hospital. Tools used for data collectionwere; an interview questionnaire sheet, a Clinical assessment form, Ultrasonography, Cardio-Tocography, Partograph, a Summary of labor sheet, a Problems-encountered sheet and aNeonatal assessment sheet. Results of present study revealed that, the incidence of preeclampsiawere higher among younger women (<25) and older (35+) than normotensivewomen. Cesarean section rates were significantly higher in the group with pre-eclampsia thanin the control group (p < 0.05). Low Apgar score, low birth weight, more admission to theNICU as well as newborn deaths were significantly higher among the pre-eclamptic group (p= 0.000). It can be concluded that, lower gestational age, less parity, higher cesarean sectionrate, low Apgar score and low birth weight neonates were more frequent in pre-eclampticwomen than in healthy pregnant women. The study recommended that: written clinicalguideline or nursing protocol for the management of patient with pre-eclampsia should bedeveloped and used by the nursing staff. Improving quality of ante-natal care for women withpreeclampsia is highly recommended at Zagazig university hospitals.